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Gap junction degradation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-190873

PubChem

R-HSA-190873

Description

The half-life of Cx is very short (1 to 5h) compared to other junctional proteins (Laird et al., 1995 ; Fallon and Goudenough, 1981). Connexins are targeted for degradation by the proteasome and the lysosome. Degradation appears to involve the phosphorylation of Connexins as well as their interactions with other proteins (Piehl et al., 2007).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 11 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P09496	Clathrin light chain A	CLTA	view
P09497	Clathrin light chain B	CLTB	view
P50570	Dynamin-2	DNM2 DYN2	view
P53675	Clathrin heavy chain 2	CLH22 CLTCL CLTCL1 CLTD	view
P60709	Actin, cytoplasmic 1	ACTB	view
P63261	Actin, cytoplasmic 2	ACTG ACTG1	view
P98082	Disabled homolog 2	DAB2 DOC2	view
Q00610	Clathrin heavy chain 1	CLH17 CLTC CLTCL2 KIAA0034	view
Q05193	Dynamin-1	DNM DNM1	view
Q96CW1	AP-2 complex subunit mu	AP2M1 CLAPM1 KIAA0109	view

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