GlyCosmos Portal

Submissions

Formation of annular gap junctions

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-196025

PubChem

R-HSA-196025

Description

Gap junction plaque internalization and the disruption cell communication requires a reorganization of Cx molecular interactions. Proteins including Dab-2, AP-2, Dynamin and Myosin VI associate with gap junction plaques permitting the internalisation of plaques after clathrin association (Piehl et al., 2007). Until now, two kinds of annular gap junctions have been described. The first is a small vesicle like structure which permits gap junction plaque renewal without arrest of functionality (Jordan et al., 2001). The second is a large annular structure, composed primarily of the junctional plaques of two adjacent cells (Jordan et al., 2001; Segretain et al., 2004).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P09496	Clathrin light chain A	CLTA	view
P09497	Clathrin light chain B	CLTB	view
P50570	Dynamin-2	DNM2 DYN2	view
P53675	Clathrin heavy chain 2	CLH22 CLTCL CLTCL1 CLTD	view
P60709	Actin, cytoplasmic 1	ACTB	view
P63261	Actin, cytoplasmic 2	ACTG ACTG1	view
P98082	Disabled homolog 2	DAB2 DOC2	view
Q00610	Clathrin heavy chain 1	CLH17 CLTC CLTCL2 KIAA0034	view
Q05193	Dynamin-1	DNM DNM1	view
Q96CW1	AP-2 complex subunit mu	AP2M1 CLAPM1 KIAA0109	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.