GlyCosmos Portal

Submissions

TCF dependent signaling in response to WNT

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-201681

PubChem

R-HSA-201681

Description

19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of so-called 'canonical' and 'non-canonical' WNT signaling. In the canonical WNT signaling pathway, binding of a WNT ligand to the Frizzled (FZD) and lipoprotein receptor-related protein (LRP) receptors results in the inactivation of the destruction complex, the stabilization and nuclear translocation of beta-catenin and subsequent activation of T-cell factor/lymphoid enhancing factor (TCF/LEF)-dependent transcription. Transcriptional activation in response to canonical WNT signaling controls processes such as cell fate, proliferation and self renewal of stem cells, as well as contributing to oncogenesis (reviewed in MacDonald et al, 2009; Saito-Diaz et al, 2013; Kim et al, 2013).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 29 in total

1

2

3

Next ›

Last »
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14640	Segment polarity protein dishevelled homolog DVL-1	DVL1	view
O14904	Protein Wnt-9a	WNT14 WNT9A	view
O75197	Low-density lipoprotein receptor-related protein 5	LR3 LRP5 LRP7	view
O75581	Low-density lipoprotein receptor-related protein 6	LRP6	view
O94907	Dickkopf-related protein 1	DKK1 UNQ492/PRO1008	view
O95271	Poly [ADP-ribose] polymerase tankyrase-1	PARP5A PARPL TIN1 TINF1 TNKS TNKS1	view
P04628	Proto-oncogene Wnt-1	INT1 WNT1	view
P34925	Tyrosine-protein kinase RYK	JTK5A RYK	view
P35222	Catenin beta-1	CTNNB CTNNB1 OK/SW-cl.35 PRO2286	view
P41221	Protein Wnt-5a	WNT5A	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_001829	Q9BQB4	Sclerostin	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.