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Basigin interactions

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-210991

PubChem

R-HSA-210991

Description

Basigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interactions involved in various immunologic phenomena, differentiation, and development, but a major function of basigin is stimulation of synthesis of several matrix metalloproteinases. Basigin also induces angiogenesis via stimulation of VEGF production.
Basigin has an extracellular region with two Ig-like domains of which the N-term Ig-like domain is involved in interactions. It undergoes interactions between basigin molecules on opposing cells or on neighbouring cells. It also interacts with a variety of other proteins like caveolin-1, cyclophilins, integrins and annexin II that play important roles in cell proliferation, energy metabolism, migration, adhesion and motion, especially in cancer metastasis.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 17 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15427	Monocarboxylate transporter 4	MCT3 MCT4 SLC16A3	view
P03956	Interstitial collagenase	CLG MMP1	view
P05026	Sodium/potassium-transporting ATPase subunit beta-1	ATP1B ATP1B1 hCG_37798	view
P05556	Integrin beta-1	FNRB ITGB1 MDF2 MSK12	view
P08195	Amino acid transporter heavy chain SLC3A2	MDU1 SLC3A2	view
P14415	Sodium/potassium-transporting ATPase subunit beta-2	ATP1B2	view
P16150	Leukosialin	CD43 SPN	view
P20916	Myelin-associated glycoprotein	GMA MAG	view
P23229	Integrin alpha-6	ITGA6	view
P26006	Integrin alpha-3	ITGA3 MSK18	view

Displaying **all 2** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_000779	P20916	Myelin-associated glycoprotein	view
GL_004606	P35613	Basigin	view

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