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Hyaluronan metabolism

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2142845

PubChem

R-HSA-2142845

Description

Hyaluronan (hyaluronic acid, hyaluronate or HA) is an anionic glycosaminoglycan (GAG) distributed widely throughout connective, epithelial, and neural tissues and most abundant in the extracellular matrix and skin. HA is unique among the GAGs in that it is not sulfated and is not found covalently attached to proteins as a proteoglycan. HA polymers are very large (they can reach molecular weights of 10 million Da) and can displace a large volume of water making them excellent lubricators and shock absorbers. Another unique feature of HA is that it is synthesized at the plasma membrane unlike other GAGs which are formed in the Golgi. HA is a polymer of the disaccharide unit D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3 glycosidic bonds (Toole 2000, 2004, Volpi et al. 2009).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00219	Hyaluronan synthase 3	HAS3	view
O15440	ATP-binding cassette sub-family C member 5	ABCC5 MRP5	view
O75330	Hyaluronan mediated motility receptor	HMMR IHABP RHAMM	view
P16070	CD44 antigen	CD44 LHR MDU2 MDU3 MIC4	view
Q12891	Hyaluronidase-2	HYAL2 LUCA2	view
Q8WWQ8	Stabilin-2	FEEL2 FELL FEX2 HARE STAB2	view
Q92819	Hyaluronan synthase 2	HAS2	view
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	CRSBP1 HAR LYVE1 UNQ230/PRO263 XLKD1 hCG_23149	view

Displaying 1 entry
GlyTouCan ID	KEGG GLYCAN	ChEBI	Pathway Viewer
G35674CY	G10008	64024	view

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