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Abacavir transmembrane transport

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2161517

PubChem

R-HSA-2161517

Description

Cytosolic levels of abacavir are determined by the balance of its facilitated diffusion into the cell mediated by organic cation transporters SLC22A1, 2, and 3, and its ATP-dependent efflux from cells mediated by ABCG2 and ABCB1 (Klaasen and Aleksunes 2010; Pan et al. 2007; Shaik et al. 2007).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15244	Solute carrier family 22 member 2	OCT2 SLC22A2	view
O15245	Solute carrier family 22 member 1	OCT1 SLC22A1	view
O75751	Solute carrier family 22 member 3	EMTH OCT3 SLC22A3	view
P08183	ATP-dependent translocase ABCB1	ABCB1 MDR1 PGY1	view
Q9UNQ0	Broad substrate specificity ATP-binding cassette transporter ABCG2	ABCG2 ABCP BCRP BCRP1 MXR	view

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