GlyCosmos Portal

Submissions

TRIF-mediated programmed cell death

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2562578

PubChem

R-HSA-2562578

Description

TLR3 and -4 trigger TRIF-dependent programmed cell death in various human and mouse cells (Kalai M et al. 2002; Han KJ et al. 2004; Kaiser WJ and Offermann MK 2005; Estornes Y et al. 2012; He S et al. 2011). Apoptosis is a prevalent form of programmed cell death and is mediated by the activation of a set of caspases. In addition to apoptosis, TLR3/TLR4 activation induces RIP3-dependent necroptosis. These two programmed cell-death pathways may suppress each other. When the caspase activity is impaired or inhibited, certain cell types switch the apoptotic death program to necroptosis in response to various stimuli (TNF, Fas, viral infection and other stress stimuli) (Kalai M et al. 2002; Weber A et al. 2010; Feoktistova M et al. 2011, Tenev et al 2011).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00206	Toll-like receptor 4	TLR4	view
P08571	Monocyte differentiation antigen CD14	CD14	view
Q13158	FAS-associated death domain protein	FADD GIG3 MORT1	view
Q13546	Receptor-interacting serine/threonine-protein kinase 1	RIP RIP1 RIPK1	view
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	RIP3 RIPK3	view
Q9Y6Y9	Lymphocyte antigen 96	ESOP1 LY96 MD2	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.