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IRF3-mediated induction of type I IFN

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-3270619

PubChem

R-HSA-3270619

Description

TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are central regulators of type-I interferon induction during bacterial or viral infection. TBK1 was found to form complexes with distinct scaffolding proteins that appeared to target TBK1 to different subcellular compartments [Hemmi H et al 2004; Oganesyan G et al 2006; Chariot A et al 2002; Huang J et al 2005]. STING interacted with both TBK1 and IRF3. Once STING is stimulated, its C-terminus served as a signaling scaffold to recruit IRF3 anhd TBK1, which led to TBK1-dependent phosphorylation of IRF3. Phosphorylation of IRF3 promoted its dimerization and translocation to the nucleus, where it triggered the transcription of interferon stimulated genes (ISGs) (Tanaka Y and Chen ZJ 2012).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P12956	DNA repair protein Ku70	G22P1 XRCC6	view
P13010	DNA repair protein Ku80	G22P2 XRCC5	view
P49959	Double-strand break repair protein MRE11	HNGS1 MRE11 MRE11A	view
P78527	DNA-dependent protein kinase catalytic subunit	HYRC HYRC1 PRKDC	view
Q16666	Gamma-interferon-inducible protein 16	IFI16 IFNGIP1	view
Q86WV6	Stimulator of interferon genes protein	ERIS MITA STING STING1 TMEM173	view
Q9Y2E6	E3 ubiquitin-protein ligase DTX4	DTX4 KIAA0937 RNF155	view

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