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Cytosolic tRNA aminoacylation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-379716

PubChem

R-HSA-379716

Description

Cytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthetases, those specific for arginine, aspartate, glutamate and proline, glutamine, isoleucine, leucine, lysine, and methionine, associate to form a complex with three accessory proteins. Each of the component synthetases is active in vitro as a purified protein; complex formation is thought to channel aminoacylated tRNAs more efficiently to the site of protein synthesis in mRNA:ribosome complexes (Quevillon et al. 1999; Wolfe et al. 2003, 2005).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 17 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43324	Eukaryotic translation elongation factor 1 epsilon-1	AIMP3 EEF1E1 P18	view
O43776	Asparagine--tRNA ligase, cytoplasmic	NARS NARS1 NRS	view
P07814	Bifunctional glutamate/proline--tRNA ligase	EPRS EPRS1 GLNS PARS PIG32 QARS QPRS	view
P23381	Tryptophan--tRNA ligase, cytoplasmic	IFI53 WARS WARS1 WRS	view
P26639	Threonine--tRNA ligase 1, cytoplasmic	TARS TARS1	view
P26640	Valine--tRNA ligase	G7A VARS VARS1 VARS2	view
P47897	Glutamine--tRNA ligase	QARS QARS1	view
P49588	Alanine--tRNA ligase, cytoplasmic	AARS AARS1	view
P49589	Cysteine--tRNA ligase, cytoplasmic	CARS CARS1	view
P49591	Serine--tRNA ligase, cytoplasmic	SARS SARS1 SERS	view

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