GlyCosmos Portal

Submissions

mRNA decay by 3' to 5' exoribonuclease

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-429958

PubChem

R-HSA-429958

Description

The degradation of mRNA from 3' to 5' occurs in two steps. First, the exosome exoribonuclease complex binds the 3' end of the oligoadenylated mRNA and hydrolyzes it from 3' to 5', yielding ribonucleotides having 5'-monophosphates, until a capped oligoribonucleotide remains. Second, the scavenging decapping enzyme DCPS hydrolyzes the 7-methylguanosine cap.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q13868	Exosome complex component RRP4	EXOSC2 RRP4	view
Q15024	Exosome complex component RRP42	EXOSC7 KIAA0116 RRP42	view
Q15477	Superkiller complex protein 2	DDX13 SKI2W SKIC2 SKIV2 SKIV2L W	view
Q6PGP7	Superkiller complex protein 3	KIAA0372 SKIC3 TTC37	view
Q96B26	Exosome complex component RRP43	EXOSC8 OIP2 RRP43	view
Q96C86	m7GpppX diphosphatase	DCPS DCS1 HINT5 HSPC015	view
Q9NQT4	Exosome complex component RRP46	CML28 EXOSC5 RRP46	view
Q9Y450	HBS1-like protein	HBS1 HBS1L KIAA1038	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.