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Exosome complex component RRP42

Summary

UniProt ID: Q15024
Gene Symbol: EXOSC7 KIAA0116 RRP42
Gene ID: 23016
Organism: Homo sapiens (human)

External Links

GlyGen: Q15024
PubChem: Q15024
Re-Glyco: Q15024

Annotation

Keyword: 3D-structure Acetylation Cytoplasm Direct protein sequencing Exosome Nucleus Phosphoprotein Proteomics identification RNA-binding Reference proteome rRNA processing

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA	GO_REF
rRNA processing	TAS	PMID
RNA processing	IDA	PMID PMID
RNA processing	IEA	GO_REF
RNA catabolic process	NAS	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA metabolic process [inference]

rRNA processing

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

rRNA catabolic process

snRNA metabolic process [inference]

snRNA processing [inference]

snRNA 3'-end processing [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA metabolic process [inference]

rRNA processing

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

rRNA catabolic process

snRNA metabolic process [inference]

snRNA processing [inference]

snRNA 3'-end processing [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA processing

rRNA processing

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snRNA processing [inference]

snRNA 3'-end processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snRNA 3'-end processing [inference]

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
nuclear exosome (RNase complex)	NAS	PMID
nuclear exosome (RNase complex)	IBA	GO_REF
cytoplasmic exosome (RNase complex)	NAS	PMID
cytoplasmic exosome (RNase complex)	IBA	GO_REF
exosome (RNase complex)	NAS	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear exosome (RNase complex)

nucleolar exosome (RNase complex)

catalytic complex [inference]

exoribonuclease complex [inference]

exosome (RNase complex)

nuclear exosome (RNase complex)

nucleolar exosome (RNase complex)

cytoplasmic exosome (RNase complex)

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

Displaying **all 3** entries
GO Term	Evidence Code	Reference
3'-5'-RNA exonuclease activity	TAS	PMID
RNA binding	TAS	PMID
mRNA 3'-UTR AU-rich region binding	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

exonuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-RNA exonuclease activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-RNA exonuclease activity

RNA nuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding [inference]

mRNA 3'-UTR binding [inference]

mRNA 3'-UTR AU-rich region binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
90				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
ATF4 activates genes in response to endoplasmic reticulum stress	Homo sapiens
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	Homo sapiens
KSRP (KHSRP) binds and destabilizes mRNA	Homo sapiens
Major pathway of rRNA processing in the nucleolus and cytosol	Homo sapiens
Nuclear RNA decay	Homo sapiens
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	Homo sapiens
mRNA decay by 3' to 5' exoribonuclease	Homo sapiens

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