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Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-450513

PubChem

R-HSA-450513

Description

Tristetraproline (TTP) binds RNAs that contain AU-rich elements and recruits enzymes that degrade RNA. TTP interacts with the exosome (3' to 5' exonuclease), XRN1 (5' to 3' exonuclease), and the decapping enzymes DCP1 and DCP2a.
The activity of TTP is regulated by phosphorylation. MK2 phosphorylates TTP, which then binds 14-3-3.The interaction with 14-3-3 prevents phosphorylated TTP from entering stress granules and stabilizes mRNA bound by phosphorylated TTP. Tristetraproline is known to bind AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos). Mice deficient in TTP exhibit arthritis, weight loss, skin lesions, autoimmunity, and myeloid hyperplasia.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q13868	Exosome complex component RRP4	EXOSC2 RRP4	view
Q15024	Exosome complex component RRP42	EXOSC7 KIAA0116 RRP42	view
Q8IZH2	5'-3' exoribonuclease 1	SEP1 XRN1	view
Q92973	Transportin-1	KPNB2 MIP1 TNPO1 TRN	view
Q96B26	Exosome complex component RRP43	EXOSC8 OIP2 RRP43	view
Q9NPI6	mRNA-decapping enzyme 1A	DCP1A SMIF	view
Q9NQT4	Exosome complex component RRP46	CML28 EXOSC5 RRP46	view

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