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Zinc influx into cells by the SLC39 gene family

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-442380

PubChem

R-HSA-442380

Description

The SLC39 gene family encode zinc transporters belonging to the ZIP (Zrt-, Irt-like proteins) family of metal ion transporters. All ZIPs transport metal ions into the cytoplasm of cells, be it across cellular membranes or from intracellular compartments. To date, there are 14 human SLC39 genes that encode the zinc transporters hZIP1-14. There are 9 members which belong to a subfamily of the ZIPs called the LZTs (LIV-1 subfamily of ZIP zinc transporters) (Taylor KM and Nicholson RI, 2003). Of these 14 proteins, four (hZIP9, 11, 12 and 13) have no function determined yet (Eide DJ, 2004).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q13433	Zinc transporter ZIP6	LIV1 SLC39A6 ZIP6	view
Q15043	Metal cation symporter ZIP14	KIAA0062 SLC39A14 ZIP14 hCG_15998	view
Q6P5W5	Zinc transporter ZIP4	SLC39A4 ZIP4	view
Q6ZMH5	Zinc transporter ZIP5	SLC39A5 ZIP5	view
Q92504	Zinc transporter SLC39A7	HKE4 RING5 SLC39A7	view
Q9C0K1	Metal cation symporter ZIP8	BIGM103 PP3105 SLC39A8 ZIP8	view
Q9ULF5	Zinc transporter ZIP10	KIAA1265 SLC39A10 ZIP10	view

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