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Repression of WNT target genes

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-4641265

PubChem

R-HSA-4641265

Description

In the absence of a WNT signal, many WNT target genes are repressed by Groucho/TLE. Groucho was initially identified in Drosophila, where it has been shown to interact with a variety of proteins to repress transcription (reviewed in Turki-Judeh and Courey, 2012). Groucho proteins, including the 4 human homologues (transducin-like enhancer of split (TLE) 1-4), do not bind DNA directly but instead are recruited to target genes through interaction with DNA-binding transcription factors including TCF/LEF (Brantjes et al, 2001; reviewed in Chen and Courey, 2000). Groucho proteins are believed to oligomerize in a manner that depends on an N-terminal glutamine-rich Q domain, and oligomerization may be important for function (Song et al, 2004; Pinto and Lobe, 1996). Groucho/TLE proteins affect levels of gene expression by interacting with the core transcriptional machinery as well as by modfiying chromatin structure through direct interaction with histones and recruitment of histone deacetylases, among other mechanisms (reviewed in Turki-Judeh and Courey, 2012). In addition to the four TLE proteins, human cells also include a truncated TLE-like protein called amino-terminal enhancer of split (AES) which contains the N-terminal Q domain but lacks much of the C-terminal sequence of TLE proteins, including the WD domain which is important for many protein-protein interactions. AES is believed to act as a dominant negative, since it is able to heter-oligomerize with full-length TLE proteins to form non-functional complexes (Brantjes et al, 2001; reviewed in Beagle and Johnson, 2010).

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P56545	C-terminal-binding protein 2	CTBP2	view
Q04724	Transducin-like enhancer protein 1	TLE1	view
Q04725	Transducin-like enhancer protein 2	TLE2	view
Q04726	Transducin-like enhancer protein 3	KIAA1547 TLE3	view
Q04727	Transducin-like enhancer protein 4	GRG4 KIAA1261 TLE4	view
Q08117	TLE family member 5	AES GRG GRG5 TLE5	view
Q13547	Histone deacetylase 1	HDAC1 RPD3L1	view
Q9UJU2	Lymphoid enhancer-binding factor 1	LEF1	view

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