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Presynaptic function of Kainate receptors

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-500657

PubChem

R-HSA-500657

Description

Kainate receptors in the presynaptic neuron are involved in modulating the release of neurotransmitters like glutamate and gamma amino butyric acid (GABA). This activity of Kainate receptors is independent of ionic fluxes through the channel. Homomeric kainate receptors containing GRIK3 are shown to be involved in this process. Kainate receptors in these neurons bind G-protein coupled receptors that activate phospholipase C which eventually triggers the release of Ca2+ from the intracellular stores. The released Ca2+ further initiates the fusion and release of vesicles containing the neurotransmitter.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	GNB1	view
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	PLCB2	view
Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	PLCB3	view
Q13003	Glutamate receptor ionotropic, kainate 3	GLUR7 GRIK3	view
Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	GNB4	view
Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	KIAA0581 PLCB1	view

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