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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Summary
- UniProt ID
- Q9NQ66
- Gene Symbol
- KIAA0581 PLCB1
- Gene ID
- 23236
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- Alternative splicing Calcium Cytoplasm Epilepsy Hydrolase Lipid degradation Membrane Nucleus Palmitate Phosphoprotein Proteomics identification Reference proteome Transducer
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| G2/M transition of mitotic cell cycle | ||
| G2/M transition of mitotic cell cycle | ||
| signal transduction | ||
| signal transduction | ||
| G protein-coupled receptor signaling pathway |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell cycle [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| phosphatidylinositol-4,5-bisphosphate phospholipase C activity | ||
| phosphatidylinositol-4,5-bisphosphate phospholipase C activity | ||
| phosphatidylinositol-4,5-bisphosphate phospholipase C activity | ||
| phosphatidylinositol-4,5-bisphosphate phospholipase C activity | ||
| C-type glycerophospholipase activity |
Sequence
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEELGGDIPGKEFDTPL
Glycosylation Sites
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Acetylcholine regulates insulin secretion | Homo sapiens |
| Ca2+ pathway | Homo sapiens |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | Homo sapiens |
| G alpha (q) signalling events | Homo sapiens |
| G beta:gamma signalling through PLC beta | Homo sapiens |
| PLC beta mediated events | Homo sapiens |
| Presynaptic function of Kainate receptors | Homo sapiens |
| Synthesis of IP3 and IP4 in the cytosol | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080459 | developmental and epileptic encephalopathy 12 | |
| DOID:0050908 | myelodysplastic syndrome |
