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PLC beta mediated events

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-112043

PubChem

R-HSA-112043

Description

The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43865	S-adenosylhomocysteine hydrolase-like protein 1	AHCYL1 DCAL IRBIT XPVKONA	view
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	PLCB2	view
Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	PLCB3	view
Q14571	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2	ITPR2	view
Q14573	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3	ITPR3	view
Q14643	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1	INSP3R1 ITPR1	view
Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	KIAA0581 PLCB1	view

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