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XAV939 stabilizes AXIN

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5545619

PubChem

R-HSA-5545619

Description

XAV939 binds to the catalytic sites of tankyrase 1 and 2 and inhibits the ADP-ribosylation of AXIN1 and 2. Treatment of cells with XAV939 significantly increases the protein, but not the mRNA levels of AXIN1 and 2 and supports a strong increase in the level of GSK3beta-AXIN complexes. These cells also show increased phosphorylation of beta-catenin, decreased beta-catenin protein levels and a corresponding decrease in beta-catenin dependent transcription. Treatment of DLD-1 cells with XAV939 has also been shown to inhibit proliferation (Huang et al, 2009). XAV939 has not been tested in a clinical setting.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O95271	Poly [ADP-ribose] polymerase tankyrase-1	PARP5A PARPL TIN1 TINF1 TNKS TNKS1	view
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	PARP5B TANK2 TNKL TNKS2	view

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