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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Poly [ADP-ribose] polymerase tankyrase-2
Summary
- UniProt ID
- Q9H2K2
- Gene Symbol
-
- TNKS2
- PARP5B
- TANK2
- TNKL
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9H2K2
- PubChem
- Q9H2K2
- The Human Metabolome Database
- HMDBP00901
- The O-GlcNAc Database
- Q9H2K2
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- ANK repeat
- Cytoplasm
- Glycosyltransferase
- Golgi apparatus
- Hydroxylation
- Membrane
- Metal-binding
- NAD
- Nucleotidyltransferase
- Nucleus
- Reference proteome
- Repeat
- Telomere
- Ubl conjugation
- Wnt signaling pathway
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| nucleus |
| nuclear envelope |
| cytoplasm |
| chromosome, telomeric region |
| cytosol |
| pericentriolar material |
| perinuclear region of cytoplasm |
| GO Term |
|---|
| enzyme binding |
| metal ion binding |
| NAD+-protein ADP-ribosyltransferase activity |
| NAD+ ADP-ribosyltransferase activity |
| nucleotidyltransferase activity |
Sequence
MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVDG
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Degradation of AXIN | Homo sapiens |
| Regulation of PTEN stability and activity | Homo sapiens |
| TCF dependent signaling in response to WNT | Homo sapiens |
| Ub-specific processing proteases | Homo sapiens |
| XAV939 stabilizes AXIN | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0060891 | Parkinson's disease 19A | |
| DOID:0060895 | Parkinson's disease 4 | |
| DOID:0060896 | Parkinson's disease 23 | |
| DOID:1324 | lung cancer | |
| DOID:1325 | bronchus cancer | |
| DOID:1380 | endometrial cancer | |
| DOID:14330 | Parkinson's disease | |
| DOID:1470 | major depressive disorder | |
| DOID:1595 | melancholic depression |
