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RHO GTPases activate KTN1

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5625970

PubChem

R-HSA-5625970

Description

GTP-bound active forms of RHO GTPases RHOA, RHOG, RAC1 and CDC42 bind kinectin (KTN1), a protein inserted in endoplasmic reticulum membranes that interacts with the cargo-binding site of kinesin and activates its microtubule-stimulated ATPase activity required for vesicle motility (Vignal et al. 2001, Hotta et al. 1996). The effect of RHOG activity on cellular morphology, exhibited in the formation of microtubule-dependent cellular protrusions, depends both on RHOG interaction with KTN1, as well as on the kinesin activity (Vignal et al. 2001). RHOG and KTN1 also cooperate in microtubule-dependent lysosomal transport (Vignal et al. 2001). The precise mechanism of kinectin-mediated Rho GTPase signaling cascade needs further elucidation, and only the first two steps, KTN1-activated RHO GTPase binding, and KTN1-kinesin-1 binding are annotated here.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P33176	Kinesin-1 heavy chain	KIF5B KNS KNS1	view
P60953	Cell division control protein 42 homolog	CDC42	view
P61586	Transforming protein RhoA	ARH12 ARHA RHO12 RHOA	view
P63000	Ras-related C3 botulinum toxin substrate 1	MIG5 RAC1 TC25	view
P84095	Rho-related GTP-binding protein RhoG	ARHG RHOG	view
Q86UP2	Kinectin	CG1 KIAA0004 KTN1	view
Q9H0B6	Kinesin light chain 2	KLC2	view
Q9NSK0	Kinesin light chain 4	KLC4 KNSL8	view

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