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Gap-filling DNA repair synthesis and ligation in TC-NER

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-6782210

PubChem

R-HSA-6782210

Description

In transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fill in the single stranded gap that remains after dual incision. DNA ligases LIG1 or LIG3, subsequently seal the single stranded nick by ligating the 3' end of the newly synthesized patch with the 5' end of incised DNA (Staresincic et al. 2009, Ogi et al. 2010, Arakawa et al. 2012, Paul-Konietzko et al. 2015).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 32 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15514	DNA-directed RNA polymerase II subunit RPB4	POLR2D	view
O60306	RNA helicase aquarius	AQR KIAA0560	view
P12004	DNA sliding clamp PCNA	PCNA	view
P15927	Replication protein A 32 kDa subunit	REPA2 RPA2 RPA32 RPA34	view
P18858	DNA ligase 1	LIG1	view
P18887	DNA repair protein XRCC1	XRCC1	view
P24928	DNA-directed RNA polymerase II subunit RPB1	POLR2 POLR2A	view
P27694	Replication protein A 70 kDa DNA-binding subunit	REPA1 RPA1 RPA70	view
P28340	DNA polymerase delta catalytic subunit	POLD POLD1	view
P30876	DNA-directed RNA polymerase II subunit RPB2	POLR2B	view

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