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COPI-independent Golgi-to-ER retrograde traffic

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-6811436

PubChem

R-HSA-6811436

Description

In addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo such as glycosylation enzymes and Shiga and Shiga-like toxin through tubular carriers rather than vesicles (White et al, 1999; Girod et al, 1999; reviewed in Heffernan and Simpson, 2014). In the absence of a COPI coat, the membrane curvature necessary to initiate tubulation may be provided through the action of phospholipase A, which hydrolyzes phospholipids at the sn2 position to yield lysophospholipids. This activity is countered by lysophospholipid acyltransferases, and the balance of these may influence whether transport tubules or transport vesicles form (de Figuiredo et al, 1998; reviewed in Bechler et al, 2012). RAB6-dependent tubules also depend on the dynein-dynactin motor complex and the hoomodimeric Bicaudal proteins (Matanis et al, 2002; Yamada et al, 2013; reviewed in Heffernan and Simpson, 2014).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 27 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NNZ2	Tubulin beta 8B	TUBB8B	view
O14576	Cytoplasmic dynein 1 intermediate chain 1	DNCI1 DNCIC1 DYNC1I1	view
O43237	Cytoplasmic dynein 1 light intermediate chain 2	DNCLI2 DYNC1LI2 LIC2	view
P04350	Tubulin beta-4A chain	TUBB4 TUBB4A TUBB5	view
P20340	Ras-related protein Rab-6A	RAB6 RAB6A	view
P47712	Cytosolic phospholipase A2	CPLA2 PLA2G4 PLA2G4A	view
P47756	F-actin-capping protein subunit beta	CAPZB	view
P52907	F-actin-capping protein subunit alpha-1	CAPZA1	view
P61163	Alpha-centractin	ACTR1A CTRN1	view
P68363	Tubulin alpha-1B chain	TUBA1B	view

Displaying **all 2** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_000883	Q10472	Polypeptide N-acetylgalactosaminyltransferase 1	view
GL_000912	Q10471	Polypeptide N-acetylgalactosaminyltransferase 2	view

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