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Tubulin alpha-1B chain

Summary

UniProt ID: P68363
Gene Symbol: TUBA1B
Gene ID: 10376
Organism: Homo sapiens (human)

External Links

GlyGen: P68363
PubChem: P68363
The Human Metabolome Database: HMDBP08594
The O-GlcNAc Database: P68363
RaftProt: P68363
O-GlcNAcAtlas: P68363
Re-Glyco: P68363

Annotation

Keyword: 3D-structure Acetylation Alternative splicing Cytoskeleton Direct protein sequencing GTP-binding Hydrolase Isopeptide bond Methylation Microtubule Nitration Phosphoprotein Proteomics identification Reference proteome Ubl conjugation

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
microtubule cytoskeleton organization	IDA	PMID
mitotic cell cycle	IBA	GO_REF
microtubule-based process	TAS	PMID
microtubule-based process	IEA	GO_REF
cytoskeleton-dependent intracellular transport	TAS	PMID

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process

microtubule cytoskeleton organization

cell cycle [inference]

mitotic cell cycle

cell division

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

response to stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to interleukin-4 [inference]

cellular response to interleukin-4

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport

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GO Term	Evidence Code	Reference
cytoplasm
microtubule	TAS	PMID
microtubule	IDA	PMID
microtubule	IEA	GO_REF
cytoplasmic microtubule	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

cytoplasmic microtubule

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GO Term	Evidence Code	Reference
double-stranded RNA binding	IDA	PMID
GTPase activity	IDA	PMID
structural molecule activity	TAS	PMID
structural constituent of cytoskeleton	IDA	PMID
structural constituent of cytoskeleton	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

structural molecule activity

structural constituent of cytoskeleton

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	PubMed ID	GlyTouCan ID	Source
6	20305658 21740066 24126823 26165356 26853435 29351928 30397120 30796923 31373491 33214551 34229054 35083852 35138101 37217939 40307207 40596516	G49108TO	The O-GlcNAc Database
41	20305658 21740066 24126823 26165356 26853435 29351928 30397120 30796923 31373491 33214551 34229054 35083852 35138101 37217939 40307207 40596516	G49108TO	The O-GlcNAc Database
51		G49108TO	GlyGen
54	20305658 21740066 24126823 26165356 26853435 29351928 30397120 30796923 31373491 33214551 34229054 35083852 35138101 37217939 40307207 40596516	G49108TO	GlyGen The O-GlcNAc Database
56	20305658 21740066 24126823 26165356 26853435 29351928 30397120 30796923 31373491 33214551 34229054 35083852 35138101 37217939 40307207 40596516	G49108TO	The O-GlcNAc Database
73	20305658 21740066 24126823 26165356 26853435 29351928 30397120 30796923 31373491 33214551 34229054 35083852 35138101 37217939 40307207 40596516	G49108TO	The O-GlcNAc Database
80	20305658 21740066 24126823 26165356 26853435 29351928 30397120 30796923 31373491 33214551 34229054 35083852 35138101 37217939 40307207 40596516	G49108TO	The O-GlcNAc Database
94	20305658 21740066 24126823 26165356 26853435 29351928 30397120 30796923 31373491 33214551 34229054 35083852 35138101 37217939 40307207 40596516	G49108TO	The O-GlcNAc Database
109	20305658 21740066 24126823 26165356 26853435 29351928 30397120 30796923 31373491 33214551 34229054 35083852 35138101 37217939 40307207 40596516	G49108TO	The O-GlcNAc Database
145	20305658 21740066 24126823 26165356 26853435 29351928 30397120 30796923 31373491 33214551 34229054 35083852 35138101 37217939 40307207 40596516	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Activation of AMPK downstream of NMDARs	Homo sapiens
Aggrephagy	Homo sapiens
Assembly and cell surface presentation of NMDA receptors	Homo sapiens
COPI-dependent Golgi-to-ER retrograde traffic	Homo sapiens
COPI-independent Golgi-to-ER retrograde traffic	Homo sapiens
COPI-mediated anterograde transport	Homo sapiens
Carboxyterminal post-translational modifications of tubulin	Homo sapiens
Cargo trafficking to the periciliary membrane	Homo sapiens
EML4 and NUDC in mitotic spindle formation	Homo sapiens
Formation of tubulin folding intermediates by CCT/TriC	Homo sapiens

Human Protein Atlas

ENSG00000123416

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlyTouCan

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Annotation

International Collaboration

Acknowledgements