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Carboxyterminal post-translational modifications of tubulin

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8955332

PubChem

R-HSA-8955332

Description

Tubulins fold into compact globular domains with less structured carboxyterminal tails. These tails vary in sequence between tubulin isoforms and are exposed on the surfaces of microtubules. They can undergo a variety of posttranslational modifications, including the attachment and removal of polyglutamate chains and in the case of alpha-tunulins the loss and reattachment of a terminal tyrosine (Tyr) residue. These modifications are associated with changes in the rigidity and stability of microtubules (Song & Brady 2015; Yu et al. 2015).
Mutations affecting these modification processes can have severe effects on phenotype (e.g., Ikegami et al. 2007). Nevertheless, the precise molecular mechanisms by which these changes in tubulin structure modulate its functions remain unclear, so these modification processes are simply annotated here as a series of chemical transformations of tubulins.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 22 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NNZ2	Tubulin beta 8B	TUBB8B	view
O95922	Polyglutamylase complex subunit TTLL1	C22orf7 TTLL1	view
P04350	Tubulin beta-4A chain	TUBB4 TUBB4A TUBB5	view
P68363	Tubulin alpha-1B chain	TUBA1B	view
P68366	Tubulin alpha-4A chain	TUBA1 TUBA4A	view
P68371	Tubulin beta-4B chain	TUBB2C TUBB4B	view
Q13509	Tubulin beta-3 chain	TUBB3 TUBB4	view
Q13885	Tubulin beta-2A chain	TUBB2 TUBB2A	view
Q14679	Tubulin monoglutamylase TTLL4	KIAA0173 TTLL4	view
Q6EMB2	Tubulin polyglutamylase TTLL5	KIAA0998 STAMP TTLL5	view

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