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U12 Dependent Splicing

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-72165

PubChem

R-HSA-72165

Description

The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that are removed by the AT-AC spliceosome, which contains distinct snRNAs (U11, U12, U4atac, U6atac) that are structurally and functionally analogous to the major spliceosome. U5 snRNA as well as many of the protein factors appear to be conserved between the two spliceosomes.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 27 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15514	DNA-directed RNA polymerase II subunit RPB4	POLR2D	view
O75533	Splicing factor 3B subunit 1	SAP155 SF3B1	view
O75643	U5 small nuclear ribonucleoprotein 200 kDa helicase	ASCC3L1 BRR2 HELIC2 KIAA0788 SNRNP200	view
O94906	Pre-mRNA-processing factor 6	C20orf14 PRPF6	view
P13984	General transcription factor IIF subunit 2	GTF2F2 RAP30	view
P14678	Small nuclear ribonucleoprotein-associated proteins B and B'	COD SNRPB SNRPB1	view
P24928	DNA-directed RNA polymerase II subunit RPB1	POLR2 POLR2A	view
P30876	DNA-directed RNA polymerase II subunit RPB2	POLR2B	view
P35269	General transcription factor IIF subunit 1	GTF2F1 RAP74	view
P62304	Small nuclear ribonucleoprotein E	SNRPE	view

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