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MIRAGE
mRNA 3'-end processing
Summary
- Organism
- Homo sapiens (human)
- Reactome
- R-HSA-72187
- PubChem
- R-HSA-72187
- Description
-
- The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first cleaved at a particular phosphodiester bond downstream of the coding sequence, (ii) the upstream fragment then receives a poly(A) tail of approximately 250 adenylate residues, whereas the downstream fragment is degraded. The two partial reactions are coupled so that reaction intermediates are usually undetectable. While 3' processing can be studied as an isolated event in vitro, it appears to be connected to transcription, splicing, and transcription termination in vivo.
The only known exception to the rule of cleavage followed by polyadenylation are the major histone mRNAs, which are cleaved but not polyadenylated.
- The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first cleaved at a particular phosphodiester bond downstream of the coding sequence, (ii) the upstream fragment then receives a poly(A) tail of approximately 250 adenylate residues, whereas the downstream fragment is degraded. The two partial reactions are coupled so that reaction intermediates are usually undetectable. While 3' processing can be studied as an isolated event in vitro, it appears to be connected to transcription, splicing, and transcription termination in vivo.
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
| UniProt ID | Protein Name | Gene Symbol | Pathway Viewer |
|---|---|---|---|
| O00148 | ATP-dependent RNA helicase DDX39A |
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| O15234 | Protein CASC3 |
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| O75152 | Zinc finger CCCH domain-containing protein 11A |
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| O94913 | Pre-mRNA cleavage complex 2 protein Pcf11 |
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| O95391 | Pre-mRNA-splicing factor SLU7 |
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| O95639 | Cleavage and polyadenylation specificity factor subunit 4 |
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| P26368 | Splicing factor U2AF 65 kDa subunit |
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| P33240 | Cleavage stimulation factor subunit 2 |
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view |
| P38919 | Eukaryotic initiation factor 4A-III |
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view |
| P51003 | Poly(A) polymerase alpha |
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view |
