GlyCosmos Portal

Submissions

The NLRP3 inflammasome

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-844456

PubChem

R-HSA-844456

Description

The NLRP3 (Cryopyrin) inflammasome is currently the best characterized. It consists of NLRP3, ASC (PYCARD) and procaspase-1; CARD8 (Cardinal) is also suggested to be a component. It is activated by a number of pathogens and bacterial toxins as well as diverse PAMPs, danger-associated molecular patterns (DAMPS) such as hyaluronan and uric acid, and exogenous irritants such as silica and asbestos (see Table S1 Schroder & Tschopp, 2010).
Mutations in NLRP3 which lead to constitutive activation are linked to the human diseases Muckle-Wells syndrome, familial cold autoinflammatory syndrome and NOMID (Ting et al. 2006), characterized by skin rashes and other symptoms associated with generalized inflammation. The cause of these symptoms is uncontrolled IL-1 beta production. Multiple studies have shown that activation of the NLRP3 inflammasome by particulate activators (e.g. Hornung et al. 2008) requires phagocytosis, but this is not required for the response to ATP, which is mediated by the P2X7 receptor (Kahlenberg & Dubyak, 2004) and appears to involve the pannexin membrane channel (Pellegrin & Suprenenant 2006). Direct binding of activators to NLRP3 has not been demonstrated and the exact process of activation is unclear, though it is speculated to involve changes in conformation that free the NACHT domain for oligomerization (Inohara & Nunez 2001, 2003).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15553	Pyrin	MEF MEFV TRIM20	view
O43586	Proline-serine-threonine phosphatase-interacting protein 1	CD2BP1 PSTPIP1	view
P05067	Amyloid-beta precursor protein	A4 AD1 APP	view
P08238	Heat shock protein HSP 90-beta	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	view
P19838	Nuclear factor NF-kappa-B p105 subunit	NFKB1	view
Q00653	Nuclear factor NF-kappa-B p100 subunit	LYT10 NFKB2	view
Q04206	Transcription factor p65	NFKB3 RELA	view
Q96RD7	Pannexin-1	MRS1 PANX1 UNQ2529/PRO6028	view
Q99572	P2X purinoceptor 7	P2RX7	view
Q9Y2Z0	Protein SGT1 homolog	SUGT1	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.