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Gastrin-CREB signalling pathway via PKC and MAPK

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-881907

PubChem

R-HSA-881907

Description

Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.Gastrin gene expression is upregulated in both a number of pre-malignant conditions and in established cancer through a variety of mechanisms. Depending on the tissue where it is expressed and the level of expression, differential processing of the polypeptide product leads to the production of different biologically active peptides. In turn, acting through the classical gastrin cholecystokinin B receptor CCK-BR, its isoforms and alternative receptors, these peptides trigger signalling pathways which influence the expression of downstream genes that affect cell survival, angiogenesis and invasion (Wank 1995, de Weerth et al. 1999, Grabowska & Watson 2007)

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01350	Gastrin	GAS GAST	view
P32239	Gastrin/cholecystokinin type B receptor	CCKBR CCKRB	view
P51812	Ribosomal protein S6 kinase alpha-3	ISPK1 MAPKAPK1B RPS6KA3 RSK2	view
Q13164	Mitogen-activated protein kinase 7	BMK1 ERK5 MAPK7 PRKM7	view
Q15418	Ribosomal protein S6 kinase alpha-1	MAPKAPK1A RPS6KA1 RSK1	view

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