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Assembly of active LPL and LIPC lipase complexes

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8963889

PubChem

R-HSA-8963889

Description

Lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (LIPC) enzymes on the lumenal surfaces of capillary endothelia mediate the hydrolysis of triglyceride molecules in circulating lipoprotein particles.
LPL is widely expressed in the body and is especially abundant in adipocytes and skeletal and cardiac myocytes. Activation of the protein requires glycosylation, dimerization, and glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), which delivers it to heparan sulfate proteoglycan (HSPG) associated with the plasma membrane. It is inactivated by proteolytic cleavage (Berryman & Bensadoun 1995; Sukonina et al. 2006; Young et al. 2011).
Expression of the LPL gene is transcriptionally regulated by Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3), which also regulates the expression of APOA4, APOA5, APOC2, CIDEC and FGF21 (Lee et al. 2011).
Maturation of LIPC enzyme requires association with LMF1 protein (or possibly, inferred from sequence similarity, LMF2). Heparin binding stabilizes LIPC in its active dimeric form (Babilonia-Rosa & Neher 2014).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 16 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43462	Membrane-bound transcription factor site-2 protease	MBTPS2 S2P	view
P02655	Apolipoprotein C-II	APC2 APOC2	view
P06727	Apolipoprotein A-IV	APOA4	view
P06858	Lipoprotein lipase	LIPD LPL	view
P09958	Furin	FUR FURIN PACE PCSK3	view
P11150	Hepatic triacylglycerol lipase	HTGL LIPC	view
P29122	Proprotein convertase subtilisin/kexin type 6	PACE4 PCSK6	view
Q14703	Membrane-bound transcription factor site-1 protease	KIAA0091 MBTPS1 S1P SKI1	view
Q68CJ9	Cyclic AMP-responsive element-binding protein 3-like protein 3	CREB3L3 CREBH HYST1481	view
Q6Q788	Apolipoprotein A-V	APOA5 RAP3 UNQ411/PRO773	view

Displaying **all 2** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_005331	Q9Y5C1	Angiopoietin-related protein 3	view
GL_005332	Q9BY76	Angiopoietin-related protein 4	view

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