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SLIT2:ROBO1 increases RHOA activity

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8985586

PubChem

R-HSA-8985586

Description

ROBO1 receptor, activated by SLIT2, binds to MYO9B and inhibits its RHOA GAP activity. SLIT2-ROBO1 signaling thus results in increased RHOA activity, which is thought to negatively regulate invasiveness of lung cancer cells (Kong et al. 2015). ROCK-mediated signaling and phosphorylation of the myosin regulatory light chain (MLRC) downstream of activated RHOA is needed for SLIT-mediated axon pathfinding in cranial motor neurons (Murray et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O94813	Slit homolog 2 protein	SLIL3 SLIT2	view
P61586	Transforming protein RhoA	ARH12 ARHA RHO12 RHOA	view
Q13459	Unconventional myosin-IXb	MYO9B MYR5	view
Q9Y6N7	Roundabout homolog 1	DUTT1 ROBO1	view

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