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Slit homolog 2 protein

Summary

UniProt ID

O94813

Gene Symbol

SLIT2
SLIL3

Organism

Homo sapiens (human)

External Links

GlyGen: O94813
PubChem: O94813
The O-GlcNAc Database: O94813

Annotation

Keyword

3D-structure
Alternative splicing
Chemotaxis
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Heparin-binding
Leucine-rich repeat
Neurogenesis
Reference proteome
Repeat
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 38 in total

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GO Term
negative regulation of cellular response to growth factor stimulus
negative regulation of chemokine-mediated signaling pathway
axon guidance
negative regulation of small GTPase mediated signal transduction
cell migration involved in sprouting angiogenesis
aortic valve morphogenesis
pulmonary valve morphogenesis
motor neuron axon guidance
ureteric bud development
negative regulation of protein phosphorylation

Displaying **all 5** entries
GO Term
extracellular region
extracellular space
cytoplasm
membrane
extracellular exosome

Displaying **all 8** entries
GO Term
identical protein binding
protein homodimerization activity
laminin-1 binding
GTPase inhibitor activity
calcium ion binding
heparin binding
proteoglycan binding
Roundabout binding

Annotation information from UniProt.

Sequence

MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 13 in total

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Position	Description	GlyTouCan ID	Source
66	N-linked (GlcNAc...) asparagine	G37412TK G49906RN G87661QW G83460ZZ G41071NU G65184UU	UniProt GlyGen
186	N-linked (GlcNAc...) asparagine	G83646BJ G41071NU G80920RR G42124LM	UniProt GlyGen
564	N-linked (GlcNAc...) asparagine	G79208PO	UniProt GlyGen
623		G83646BJ G41071NU G88520YF	UniProt GlyGen
794	N-linked (GlcNAc...) asparagine		UniProt GlyGen
799	N-linked (GlcNAc...) asparagine		UniProt GlyGen
1009	N-linked (GlcNAc...) asparagine		UniProt GlyGen
1010	N-linked (GlcNAc...) asparagine		UniProt GlyGen
1019	N-linked (GlcNAc...) asparagine		UniProt GlyGen
1183	N-linked (GlcNAc...) asparagine	G80920RR G42124LM	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Activation of RAC1	Homo sapiens
Formation of the ureteric bud	Homo sapiens
Inactivation of CDC42 and RAC1	Homo sapiens
Netrin-1 signaling	Homo sapiens
Regulation of commissural axon pathfinding by SLIT and ROBO	Homo sapiens
Regulation of expression of SLITs and ROBOs	Homo sapiens
Role of ABL in ROBO-SLIT signaling	Homo sapiens
SLIT2:ROBO1 increases RHOA activity	Homo sapiens
Signaling by ROBO receptors	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements