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MIRAGE
Slit homolog 2 protein
Summary
- UniProt ID
- O94813
- Gene Symbol
- SLIL3 SLIT2
- Gene ID
- 9353
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Alternative splicing Chemotaxis Developmental protein Differentiation Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Heparin-binding Leucine-rich repeat Neurogenesis Proteomics identification Reference proteome Repeat Secreted Signal
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| ureteric bud development | ||
| negative regulation of protein phosphorylation | ||
| cell migration involved in sprouting angiogenesis | ||
| negative regulation of leukocyte chemotaxis | ||
| aortic valve morphogenesis |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
negative regulation of locomotion [inference]
regulation of chemotaxis [inference]
regulation of cell motility [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of locomotion [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell motility [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| extracellular region | ||
| obsolete extracellular space |
|
|
| cytoplasm |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| GTPase inhibitor activity | ||
| calcium ion binding | ||
| calcium ion binding | ||
| heparin binding | ||
| heparin binding |
GO Hierarchy
Sequence
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 66 |
|
|||
| 186 |
|
|||
| 564 |
|
|||
| 623 |
|
|||
| 794 |
|
|
||
| 799 |
|
|
||
| 1009 |
|
|
||
| 1010 |
|
|
||
| 1019 |
|
|
||
| 1183 |
|
G37412TK
G49906RN
G87661QW
G83460ZZ
G41071NU
G65184UU
G83646BJ
G80920RR
G42124LM
G79208PO
G88520YF
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of RAC1 | Homo sapiens |
| Formation of the ureteric bud | Homo sapiens |
| Inactivation of CDC42 and RAC1 | Homo sapiens |
| Netrin-1 signaling | Homo sapiens |
| Regulation of commissural axon pathfinding by SLIT and ROBO | Homo sapiens |
| Regulation of expression of SLITs and ROBOs | Homo sapiens |
| Role of ABL in ROBO-SLIT signaling | Homo sapiens |
| SLIT2:ROBO1 increases RHOA activity | Homo sapiens |
| Signaling by ROBO receptors | Homo sapiens |
