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Inactivation of CDC42 and RAC1

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-428543

PubChem

R-HSA-428543

Description

Rho family GTPases, including RAC1, RHOA, and CDC42, are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed an important role for CDC42 and RAC1 in ROBO repulsion. ROBO controls the activity of Rho GTPases by interacting with a family of SLIT/ROBO-specific GAPs (SrGAPs) and Vilse/CrossGAP. SrGAPs inactivate CDC42 and Vilse/CrossGAP specifically inactivates RAC1.
It was recently implicated that SRGAP3 may inactivate RAC1 downstream of SLIT1-activated ROBO2, which promotes neurite outgrowth in mammalian dorsal root ganglion (DRG) neurons (Zhang et al. 2014).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43295	SLIT-ROBO Rho GTPase-activating protein 3	ARHGAP14 KIAA0411 KIAA1156 MEGAP SRGAP2 SRGAP3	view
O75044	SLIT-ROBO Rho GTPase-activating protein 2	ARHGAP34 FNBP2 KIAA0456 SRGAP2 SRGAP2A	view
O94813	Slit homolog 2 protein	SLIL3 SLIT2	view
P60953	Cell division control protein 42 homolog	CDC42	view
P63000	Ras-related C3 botulinum toxin substrate 1	MIG5 RAC1 TC25	view
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	ARHGAP13 KIAA1304 SRGAP1	view
Q9Y6N7	Roundabout homolog 1	DUTT1 ROBO1	view

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