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SLIT-ROBO Rho GTPase-activating protein 2

Summary

UniProt ID: O75044
Gene Symbol: ARHGAP34 FNBP2 KIAA0456 SRGAP2 SRGAP2A
Gene ID: 23380
Organism: Homo sapiens (human)

External Links

GlyGen: O75044
PubChem: O75044
The O-GlcNAc Database: O75044
O-GlcNAcAtlas: O75044
Re-Glyco: O75044

Annotation

Keyword: 3D-structure Cell membrane Cell projection Chromosomal rearrangement Coiled coil Cytoplasm Cytoplasmic vesicle GTPase activation Methylation Neurogenesis Nucleus Phosphoprotein Postsynaptic cell membrane Proteomics identification Reference proteome SH3 domain

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
lamellipodium assembly involved in ameboidal cell migration	IMP	PMID
signal transduction	IEA	GO_REF
nervous system development	IBA	GO_REF
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	ISS	GO_REF
negative regulation of cell migration	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

cell adhesion [inference]

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

signal transduction

actin filament-based process [inference]

actin filament severing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell junction assembly [inference]

synapse assembly [inference]

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

plasma membrane bounded cell projection organization [inference]

pseudopodium organization [inference]

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

lamellipodium organization [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

synapse organization [inference]

synapse assembly [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure development [inference]

system development [inference]

nervous system development

dendritic spine development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	IEA	GO_REF
cytosol	ISS	GO_REF
cytosol	TAS	Reactome Reactome Reactome Reactome Reactome
cytosol	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

postsynaptic specialization [inference]

postsynaptic density

dendritic spine head

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
GTPase activator activity	TAS	Reactome Reactome
GTPase activator activity	IDA	PMID PMID
GTPase activator activity	IMP	PMID
GTPase activator activity	IBA	GO_REF
small GTPase binding	IDA	PMID PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	PubMed ID	GlyTouCan ID	Source
424		G49108TO	GlyGen
425		G49108TO	GlyGen
982	23301498 30379171 35254053 35289036 38665916 39302247 39531497	G49108TO	GlyGen The O-GlcNAc Database
983	23301498 30379171 35254053 35289036 38665916 39302247 39531497	G49108TO	GlyGen The O-GlcNAc Database
989			GlyGen
990	23301498 30379171 35254053 35289036 38665916 39302247 39531497	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
CDC42 GTPase cycle	Homo sapiens
Inactivation of CDC42 and RAC1	Homo sapiens
RAC1 GTPase cycle	Homo sapiens
RAC3 GTPase cycle	Homo sapiens
RHO GTPases Activate Formins	Homo sapiens
RHOF GTPase cycle	Homo sapiens
RHOQ GTPase cycle	Homo sapiens
RHOU GTPase cycle	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements