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RHOJ GTPase cycle

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9013409

PubChem

R-HSA-9013409

Description

This pathway catalogues RHOJ (also known as TCL or RHOI) guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), and RHOJ effectors. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOJ. RHOJ, together with RHOQ (TC10), belongs to the CDC42 subfamily of RHO GTPases and shares 85% and 78% amino acid similarity with RHOQ and CDC42, respectively (Vignal et al. 2000). RHOJ regulates the cytoskeleton, including formation of lamellipodia and actin filaments (Vignal et al. 2000, Abe et al. 2003, Aspenstrom et al. 2004, Shi et al. 2016). RHOJ is highly expressed in endothelial cells, regulating their motility and, consequently, vascular morphogenesis (Leszczynska et al. 2011; Shi et al. 2016). As a part of the VEGF signaling cascade, RHOJ promotes retinal angiogenesis (Fukushima et al. 2013). RHOJ plays a role in cancer cell migration and cancer-related angiogenesis (Shi et al. 2016). RHOJ is involved in adipocyte differentiation (Nishizuka 2003; Shi et al. 2016).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 40 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A7KAX9	Rho GTPase-activating protein 32	ARHGAP32 GRIT KIAA0712 RICS	view
O00161	Synaptosomal-associated protein 23	SNAP23	view
O00308	NEDD4-like E3 ubiquitin-protein ligase WWP2	WWP2	view
O00401	Actin nucleation-promoting factor WASL	WASL	view
O60890	Oligophrenin-1	OPHN1	view
O75914	Serine/threonine-protein kinase PAK 3	OPHN3 PAK3	view
O75962	Triple functional domain protein	TRIO	view
O96013	Serine/threonine-protein kinase PAK 4	KIAA1142 PAK4	view
P02786	Transferrin receptor protein 1	TFRC hCG_22086	view
P14923	Junction plakoglobin	CTNNG DP3 JUP	view

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