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NOTCH4 Intracellular Domain Regulates Transcription
Summary
- Organism
- Homo sapiens (human)
- Reactome
- R-HSA-9013695
- PubChem
- R-HSA-9013695
- Description
-
- In the nucleus, NOTCH4 intracellular domain fragment (NICD4) binds transcription factors RBPJ (CSL) and mastermind family members (MAML1, MAML2 or MAML3) to form the NOTCH4 co-activator complex (Lin et al. 2002). The NOTCH4 coactivator complex stimulates transcription of well-established NOTCH targets HES1, HES5, HEY1 and HEY2 in a cellular context-dependent manner (Lin et al. 2002, Raafat et al.2004, Tsunematsu et al. 2004, Bargo et al. 2010). NOTCH4 also stimulates transcription of the FLT4 (VEGFR3) gene, encoding vascular endothelial growth factor receptor-3 (Shawber et al. 2007) and ACTA2 gene, encoding smooth muscle alpha actin (Tang et al. 2008).
NICD4 inhibits TGF-beta-induced SMAD-mediated transcription via binding of NICD4 to TGF-beta activated SMAD3 (Sun et al. 2005, Grabias and Konstantopoulos 2013).
- In the nucleus, NOTCH4 intracellular domain fragment (NICD4) binds transcription factors RBPJ (CSL) and mastermind family members (MAML1, MAML2 or MAML3) to form the NOTCH4 co-activator complex (Lin et al. 2002). The NOTCH4 coactivator complex stimulates transcription of well-established NOTCH targets HES1, HES5, HEY1 and HEY2 in a cellular context-dependent manner (Lin et al. 2002, Raafat et al.2004, Tsunematsu et al. 2004, Bargo et al. 2010). NOTCH4 also stimulates transcription of the FLT4 (VEGFR3) gene, encoding vascular endothelial growth factor receptor-3 (Shawber et al. 2007) and ACTA2 gene, encoding smooth muscle alpha actin (Tang et al. 2008).
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
| UniProt ID | Protein Name | Gene Symbol | Pathway Viewer |
|---|---|---|---|
| P35916 | Vascular endothelial growth factor receptor 3 |
|
view |
| P46531 | Neurogenic locus notch homolog protein 1 |
|
view |
| P62736 | Actin, aortic smooth muscle |
|
view |
| Q04721 | Neurogenic locus notch homolog protein 2 |
|
view |
| Q06330 | Recombining binding protein suppressor of hairless |
|
view |
| Q09472 | Histone acetyltransferase p300 |
|
view |
| Q13495 | Mastermind-like domain-containing protein 1 |
|
view |
| Q13573 | SNW domain-containing protein 1 |
|
view |
| Q14469 | Transcription factor HES-1 |
|
view |
| Q8IZL2 | Mastermind-like protein 2 |
|
view |
