GlyCosmos Portal

Submissions

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9027276

PubChem

R-HSA-9027276

Description

PI3K can bind the activated EPO receptor (EPOR) by three different mechanisms: direct binding to phospho-Y479 of the EPOR, indirect binding via phosphorylated IRS2 bound to the EPOR, and indirect binding via phosphorylated GAB1 bound to the EPOR (Bouscary et al. 2003, Schmidt et al. 2004, reviewed in Kuhrt and Wojchowski 2015). PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate to yield phosphatidylinositol 3,4,5-trisphosphate which recruits AKT1 to the membrane.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PIK3CD	view
P01588	Erythropoietin	EPO	view
P19235	Erythropoietin receptor	EPOR	view
P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	PIK3C1 PIK3CB	view
P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	view
Q13480	GRB2-associated-binding protein 1	GAB1	view
Q9Y4H2	Insulin receptor substrate 2	IRS2	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.