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Erythropoietin

Summary
UniProt ID
P01588
Gene Symbol
  • EPO
Gene ID
2056
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P01588
PubChem
P01588
Re-Glyco
P01588
Annotation
Keyword
  • 3D-structure
  • Congenital erythrocytosis
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Erythrocyte maturation
  • Glycoprotein
  • Hormone
  • Pharmaceutical
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying all 4 entries
GO Term
cell body
cell surface
extracellular region
extracellular space
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 5 entries
Position Description PubMed ID GlyTouCan ID Source
51 N-linked (GlcNAc...) asparagine
65 N-linked (GlcNAc...) asparagine
110 N-linked (GlcNAc...) asparagine
153 O-linked (GalNAc...) serine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 6 entries
Pathway Name Organism
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Homo sapiens
Erythropoietin activates Phospholipase C gamma (PLCG) Homo sapiens
Erythropoietin activates RAS Homo sapiens
Erythropoietin activates STAT5 Homo sapiens
Regulation of gene expression by Hypoxia-inducible Factor Homo sapiens
Signaling by Erythropoietin Homo sapiens
Disease
Displaying entries 1 - 10 of 19 in total
DO ID Disease Name Source
DOID:0050852 limb ischemia
DOID:0080290 familial erythrocytosis 5
DOID:10652 Alzheimer's disease
DOID:11713 diabetic angiopathy
DOID:1184 nephrotic syndrome
DOID:1289 neurodegenerative disease
DOID:13268 porphyria
DOID:14330 Parkinson's disease
DOID:1686 glaucoma
DOID:224 transient cerebral ischemia
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025