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Erythropoietin activates Phospholipase C gamma (PLCG)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9027277

PubChem

R-HSA-9027277

Description

PLCG1 (Phospholipase C gamma1) or PLCG2 bound to the activated EPOR is phosphorylated on tyrosine residues by the kinase LYN (Ren et al. 1994, and inferred from mouse homologs). PLCG1 and PLCG2 produce inositol 1,4,5-trisphosphate which then activates calcium signaling, and diacylglycerol (DAG) which then activates protein kinase C (PKC).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01588	Erythropoietin	EPO	view
P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	PLC1 PLCG1	view
P19235	Erythropoietin receptor	EPOR	view
Q9Y4H2	Insulin receptor substrate 2	IRS2	view

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