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Erythropoietin activates STAT5

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9027283

PubChem

R-HSA-9027283

Description

STAT5 (STAT5A or STAT5B) directly binds the phosphorylated cytoplasmic domain of EPOR, where it is phosphorylated by JAK2 and LYN (Oda et al. 1998, inferred from mouse homologs, reviewed in Kuhrt and Wojchowski 2015). Phosphorylated STAT5 then dissociates from EPOR, dimerizes, and transits to the nucleus where it activates gene expression.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01588	Erythropoietin	EPO	view
P19235	Erythropoietin receptor	EPOR	view
P42229	Signal transducer and activator of transcription 5A	STAT5 STAT5A	view
P51692	Signal transducer and activator of transcription 5B	STAT5B	view
Q9Y4H2	Insulin receptor substrate 2	IRS2	view

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