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Erythropoietin activates RAS

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9027284

PubChem

R-HSA-9027284

Description

The RAS guanine nucleotide exchange factors SOS1 and VAV1 bind indirectly to the phosphorylated EPOR via CRKL, SHC1, and GRB2 (Miura et al. 1994, Hanazono et al. 1996, Odai et al. 1997, Arai et al. 2001, reviewed in Kuhrt et al. 2015) . The phosphorylated cytoplasmic domain of EPOR binds CRKL, which is then phosphorylated (Arai et al. 2001). Phosphorylated CRKL binds SHC1, which is then phosphorylated and binds either GRB2:SOS1 (Barber et al. 1997) or GRB2:VAV1 (Hanazono et al. 1996). SOS1 and phosphorylated VAV1 catalyze the exchange of GDP for GTP bound to RAS, that is, RAS:GDP is converted to RAS:GTP.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 9** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01111	GTPase NRas	HRAS1 NRAS	view
P01112	GTPase HRas	HRAS HRAS1	view
P01588	Erythropoietin	EPO	view
P15498	Proto-oncogene vav	VAV VAV1	view
P19235	Erythropoietin receptor	EPOR	view
P29353	SHC-transforming protein 1	SHC SHC1 SHCA	view
P46109	Crk-like protein	CRKL	view
Q07889	Son of sevenless homolog 1	SOS1	view
Q9Y4H2	Insulin receptor substrate 2	IRS2	view

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