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TRAF6 mediated NF-kB activation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-933542

PubChem

R-HSA-933542

Description

The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kappaB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I (DDX58)/MDA5 (IFIH1) pathway is largely unknown. According to the study done by Yoshida et al. the DDX58:MAVS pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kappaB and MAP Kinases for optimal induction of type I IFNs.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 12 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB IKKB	view
O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	CHUK IKKA TCF16	view
O95786	Antiviral innate immune response receptor RIG-I	DDX58 RIGI	view
P05067	Amyloid-beta precursor protein	A4 AD1 APP	view
P09429	High mobility group protein B1	HMG1 HMGB1	view
P19838	Nuclear factor NF-kappa-B p105 subunit	NFKB1	view
Q00653	Nuclear factor NF-kappa-B p100 subunit	LYT10 NFKB2	view
Q04206	Transcription factor p65	NFKB3 RELA	view
Q13233	Mitogen-activated protein kinase kinase kinase 1	MAP3K1 MAPKKK1 MEKK MEKK1	view
Q15109	Advanced glycosylation end product-specific receptor	AGER RAGE	view

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