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Purinergic signaling in leishmaniasis infection

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9660826

PubChem

R-HSA-9660826

Description

The purinoreceptors are divided into inotropic (P2XR) and metabotropic (P2YR) subtypes whose ligands are the nucleotides ATP and UDP respectively (Cekic et al. 2016). The binding of these nucleotides to their receptors on macrophages have been associated with the activation of the inflammasome leading to the subsequent activation of interleukin 1 beta (IL1β) and TNF-α (Cekic et al. 2016 & Figueiredo et al. 2016). The liberation of ATP comes from tissues facing stressful stimuli such as a tissue injury or microorganism infection, amongst others. As a regulatory mechanism, certain enzymes can reduce ATP to Adenosine and a nucleoside can stimulate signalling pathways leading to the synthesis of anti-inflammatory cytokines (Cekic et al. 2016).

The activation of the receptor P2RX7 was shown to lead to the activation of killing mechanisms or cell death programs, ending up in the elimination of microbes such as Leishmania amazonensis, Mycobacterium tuberculosis, Chlamydia psittaci, and Toxoplasma gondii (Coutinho-Silva et al. 2012 & Idzko, 2014).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 18 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15553	Pyrin	MEF MEFV TRIM20	view
O43586	Proline-serine-threonine phosphatase-interacting protein 1	CD2BP1 PSTPIP1	view
O75356	Nucleoside diphosphate phosphatase ENTPD5	CD39L4 ENTPD5 PCPH	view
P01024	Complement C3	C3 CPAMD1 HEL-S-62p	view
P01583	Interleukin-1 alpha	IL1A IL1F1	view
P05067	Amyloid-beta precursor protein	A4 AD1 APP	view
P08238	Heat shock protein HSP 90-beta	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	view
P08311	Cathepsin G	CTSG	view
P19838	Nuclear factor NF-kappa-B p105 subunit	NFKB1	view
P21589	5'-nucleotidase	NT5 NT5E NTE	view

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