GlyCosmos Portal

Submissions

Impaired BRCA2 binding to RAD51

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9709570

PubChem

R-HSA-9709570

Description

A critical function of BRCA2 is to bind RAD51 and nucleate RAD51 filament formation on single-stranded DNA. BRCA2 has two regions that interact with RAD51: 8 BRC repeats encoded by exon11 (Bork et al. 1996, Wong et al. 1997) and a C-terminal RAD51 binding domain called TR2 (Sharan et al. 1997).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 21 in total

1

2

3

Next ›

Last »
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60934	Nibrin	NBN NBS NBS1 P95	view
O75943	Cell cycle checkpoint protein RAD17	R24L RAD17	view
P15927	Replication protein A 32 kDa subunit	REPA2 RPA2 RPA32 RPA34	view
P27694	Replication protein A 70 kDa DNA-binding subunit	REPA1 RPA1 RPA70	view
P35249	Replication factor C subunit 4	RFC4	view
P38398	Breast cancer type 1 susceptibility protein	BRCA1 RNF53	view
P40937	Replication factor C subunit 5	RFC5	view
P49959	Double-strand break repair protein MRE11	HNGS1 MRE11 MRE11A	view
P51587	Breast cancer type 2 susceptibility protein	BRCA2 FACD FANCD1	view
P54132	RecQ-like DNA helicase BLM	BLM RECQ2 RECQL3	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.