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TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-975110

PubChem

R-HSA-975110

Description

In plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and IRAKs and translocates to the nucleus upon phosphorylation (Kawai et al 2004; Uematsu et al 2005).
TLR7/8 signaling was shown to induce IRF5 activation along with IRF7 [Schoenemeyer et al 2005], while IRF8 [Tsujimura H et al 2004] and IRF1 were reported to be implicated in TLR9 signaling.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P51617	Interleukin-1 receptor-associated kinase 1	IRAK IRAK1	view
P62979	Ubiquitin-ribosomal protein eS31 fusion protein	RPS27A UBA80 UBCEP1	view
P62987	Ubiquitin-ribosomal protein eL40 fusion protein	UBA52 UBCEP2	view
Q92985	Interferon regulatory factor 7	IRF7	view
Q99836	Myeloid differentiation primary response protein MyD88	MYD88	view
Q9NR96	Toll-like receptor 9	TLR9 UNQ5798/PRO19605	view
Q9NWZ3	Interleukin-1 receptor-associated kinase 4	IRAK4	view
Q9NYK1	Toll-like receptor 7	TLR7 UNQ248/PRO285	view

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