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TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-975138

PubChem

R-HSA-975138

Description

TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P51617	Interleukin-1 receptor-associated kinase 1	IRAK IRAK1	view
Q13233	Mitogen-activated protein kinase kinase kinase 1	MAP3K1 MAPKKK1 MEKK MEKK1	view
Q99836	Myeloid differentiation primary response protein MyD88	MYD88	view
Q9NR96	Toll-like receptor 9	TLR9 UNQ5798/PRO19605	view
Q9NWZ3	Interleukin-1 receptor-associated kinase 4	IRAK4	view
Q9NYK1	Toll-like receptor 7	TLR7 UNQ248/PRO285	view

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