GlyCosmos Portal

Submissions

SARS-CoV-2 modulates host translation machinery

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9754678

PubChem

R-HSA-9754678

Description

SARS-CoV-2 encodes several proteins that have been implicated in shutting off host expression (Banerjee AK et al. 2020; Finkel Y et al. 2021). This Reactome module describes SARS-CoV-2 nonstructural protein 1 (nsp1)-mediated shutdown of host protein translation by binding to the mRNA entrance channel on the 40S subunit (Banerjee AK et al. 2020), SARS-CoV-2 nsp16-mediated disruption of global mRNA splicing via binding to the 5′ splice site recognition sequence of U1 snRNA and the branchpoint recognition site of U2 snRNA, both parts of the spliceosome (Banerjee et al, 2020), and SARS-CoV-2 nsp8, nsp9-mediated suppression of protein integration into the cell membrane (Banerjee et al, 2020).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 31 in total

1

2

3

4

Next ›

Last »
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P08708	Small ribosomal subunit protein eS17	RPS17 RPS17L	view
P14678	Small nuclear ribonucleoprotein-associated proteins B and B'	COD SNRPB SNRPB1	view
P15880	Small ribosomal subunit protein uS5	RPS2 RPS4	view
P23396	Small ribosomal subunit protein uS3	OK/SW-cl.26 RPS3	view
P25398	Small ribosomal subunit protein eS12	RPS12	view
P39019	Small ribosomal subunit protein eS19	RPS19	view
P46781	Small ribosomal subunit protein uS4	RPS9	view
P46782	Small ribosomal subunit protein uS7	RPS5	view
P57678	Gem-associated protein 4	GEMIN4	view
P60866	Small ribosomal subunit protein uS10	RPS20	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.