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Nuclear events mediated by NFE2L2

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9759194

PubChem

R-HSA-9759194

Description

In response to chemical and other stressors, the constitutive degradation of NFE2L2 by the KEAP1:CUL3:26S proteasome system is disrupted, allowing NFE2L2 to accumulate. Stabilized NFE2L2 translocates to the nucleus where it binds to antioxidant response elements (AREs) in the promoters and enhancers of target genes to upregulate their expression (reviewed in Baird and Yamamoto, 2020).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15525	Transcription factor MafG	MAFG	view
O60675	Transcription factor MafK	MAFK	view
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	AMPK AMPK2 PRKAA2	view
Q09472	Histone acetyltransferase p300	EP300 P300	view
Q13501	Sequestosome-1	ORCA OSIL SQSTM1	view
Q14145	Kelch-like ECH-associated protein 1	INRF2 KEAP1 KIAA0132 KLHL19	view
Q16236	Nuclear factor erythroid 2-related factor 2	NFE2L2 NRF2	view
Q92793	CREB-binding protein	CBP CREBBP	view

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