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MIRAGE
Nuclear factor erythroid 2-related factor 2
Summary
- UniProt ID
- Q16236
- Gene Symbol
- NFE2L2 NRF2
- Gene ID
- 4780
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Acetylation Activator Alternative splicing Cytoplasm DNA-binding Disease variant Glycation Host-virus interaction Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription regulation Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| response to ischemia | ||
| regulation of transcription by RNA polymerase II | ||
| regulation of transcription by RNA polymerase II | ||
| regulation of transcription by RNA polymerase II | ||
| inflammatory response |
|
|
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
response to stress [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| transcription cis-regulatory region binding | ||
| transcription cis-regulatory region binding | ||
| transcription cis-regulatory region binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO Hierarchy
Sequence
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 103 |
|
|||
| 462 |
|
|
||
| 472 |
|
|
||
| 487 |
|
|
||
| 499 |
|
|
||
| 569 |
|
|
||
| 574 |
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CHD6, CHD7, CHD8, CHD9 subfamily | Homo sapiens |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | Homo sapiens |
| Heme signaling | Homo sapiens |
| KEAP1-NFE2L2 pathway | Homo sapiens |
| NFE2L2 regulates pentose phosphate pathway genes | Homo sapiens |
| NFE2L2 regulating ER-stress associated genes | Homo sapiens |
| NFE2L2 regulating MDR associated enzymes | Homo sapiens |
| NFE2L2 regulating TCA cycle genes | Homo sapiens |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | Homo sapiens |
| NFE2L2 regulating inflammation associated genes | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:399 | tuberculosis | |
| DOID:83 | cataract | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:10652 | Alzheimer's disease | |
| DOID:4448 | macular degeneration |
