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Regulation of MITF-M-dependent genes involved in apoptosis

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9824594

PubChem

R-HSA-9824594

Description

MITF contributes to cellular survival through regulation of anti-apoptotic factors such as BCL2 and BIRC7 (McGill et al, 2002; Dynek et al, 2008; Strub et al, 2011; reviewed in Cheli et al, 2010). Consistent with this, MITF is required for survival of melanoblasts during embryogenesis (Hodgkinson et al, 1993; Opdecamp et al, 1997; Nakayama et al, 1998). MITF may also contribute to survival through regulation of DICER, which in turn regulates expression of a number of genes by virtue of its processing of microRNAs (Levy et al, 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 11 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q13547	Histone deacetylase 1	HDAC1 RPD3L1	view
Q7Z4N2	Transient receptor potential cation channel subfamily M member 1	LTRPC1 MLSN MLSN1 TRPM1	view
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	CAGH26 KIAA1460 TNRC6 TNRC6A	view
Q96ST3	Paired amphipathic helix protein Sin3a	SIN3A	view
Q9H9G7	Protein argonaute-3	AGO3 EIF2C3	view
Q9HCE1	Helicase MOV-10	KIAA1631 MOV10	view
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	KIAA1582 TNRC6C	view
Q9UKV8	Protein argonaute-2	AGO2 EIF2C2	view
Q9UL18	Protein argonaute-1	AGO1 EIF2C1	view
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	KIAA1093 TNRC6B	view

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