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Regulation of MITF-M-dependent genes involved in cell cycle and proliferation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9825892

PubChem

R-HSA-9825892

Description

Depending on the overall level of activity, MITF may have a proliferative or antiproliferative role. In what has been termed a rheostat model of action, low-levels of MITF activity are associated with dedifferentiation, invasion, p27kip (CDKN1B)-dependent cell cycle arrest and low proliferative rates, while higher MITF activity drive proliferation by upregulation of cell-cycle and mitotic genes such as CDK2, CCNB1, CCND1, MET, PLK1, CENPA and NDC80 (Carreira et al, 2006; Strub et al, 2011; McGill et al, 2006; Beuret et al, 2007; Webster et al, 2014). At even higher MITF levels, cell-cycle is arrested by virtue of expression of p21 (CDKN1A) and p16 (CDKN2A) (Carreira et al, 2005; Loercher et al, 2005; reviewed in Goding and Arnheiter, 2019). This rheostat model of MITF activity and target gene expression can also be used to describe the role of MITF in the development of melanoma, with activation of different groups of target genes driving proliferation and invasion without activation of pigmentation genes (Hoek and Goding, 2010; reviewed in Mort et al, 2015; White and Zon, 2008).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P08581	Hepatocyte growth factor receptor	MET	view
P30305	M-phase inducer phosphatase 2	CDC25B CDC25HU2	view
P35222	Catenin beta-1	CTNNB CTNNB1 OK/SW-cl.35 PRO2286	view
P53350	Serine/threonine-protein kinase PLK1	PLK PLK1	view
Q13207	T-box transcription factor TBX2	TBX2	view
Q13547	Histone deacetylase 1	HDAC1 RPD3L1	view
Q96ST3	Paired amphipathic helix protein Sin3a	SIN3A	view
Q9UJU2	Lymphoid enhancer-binding factor 1	LEF1	view

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